This analysis and discussion activity introduces Victoria Gray whose severe sickle cell anemia was effectively treated by gene editing with CRISPR-Cas.
To begin, students review the molecular biology of sickle cell anemia, transcription and translation.
Next, they learn how bacteria use CRISPR-Cas to defend against viral infections. Then, students examine some of the research findings that scientists used to identify the target for gene editing.
Finally, students analyze the CRISPR-Cas gene editing treatment for sickle cell anemia.
The Teacher Notes present an optional additional video and question to stimulate students to consider the ethical controversies related to potential uses of CRISPR-Cas.